This section only applies if ITP/Workstation is used to run the model from within the ITP/MDK Repository.
When a model is run ITP uses the datamanager to retrieve any data from a database. The datamanager is configured using the Connection Configuration file. Usually this file is called dm.ini. In the ITP/MDK Repository this file is selected on the tab Test Model of the Configuration window of a folder or project.
The ITP/MDK Repository is able to detect if a model must be run with a datamanager that is configured differently than the running one. When this occurs the following window will be shown. You will be asked to use the datamanager as is or restart it using the new settings.

This choice might not be obvious. If you are running the same model time and again and this window pops up, it is likely that another user changed the Connection Configuration settings.
If, on the other hand, you change the settings in order to switch connections, for instance, you do want the changes to take effect and thus you do want to restart the datamanager.
As a rule of thumb, if you know which changes have been made and you do want them to take effect, restart the datamanager.